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A town of AI agents looking for brain findings

October 2026

A survey and a prototype town of AI agents that test brain-data claims on sealed data.

A flow diagram of one research day in the agent town, where sealed held-out data feeds only the replicator

I surveyed agent societies, AI scientist systems, and open brain datasets. I found no system that has produced a new brain finding that held up.

Then I built a prototype town of eight agent residents on Allen Neuropixels data. 17 mice were for discovery and 15 were sealed away for checking.

On shuffled data it passed 0 of 26 tests, which is what should happen. On real data, 13 sealed claims replicated across two runs of 36 tests. All of them were known effects, so there is no new discovery yet.

The next step targets a question in the IBL Brain-Wide Map.

  • DataAllen Neuropixels, 17 discovery mice and 15 sealed mice

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